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About Tasigna

Tasigna Safety and Tolerability

Tasigna is generally well tolerated and has demonstrated a low incidence of cross-intolerance with Glivec (imatinib mesylate). Tasigna also was associated with a low rate of Grade 3/4 nonhematologic AEs, including low AEs related to fluid retention.

Most nonhematologic AEs were mild to moderate in severity.

  • The most common AEs in the chronic phase were rash, pruritus, nausea, headache, and fatigue.

Tasigna was associated with a low incidence of AEs related to fluid retention

  • Low incidence (<1%) of Grade 3/4 pleural or pericardial effusions

Tasigna has a negligible incidence of cross-intolerance with Glivec

Tasigna had a low incidence of cross-intolerance with Glivec as well as a high median dose intensity

The most common hematologic AEs (Grade 3/4) were neutropenia and thrombocytopenia.

The most common hematologic AEs (Grade 3/4) were neutropenia and thrombocytopenia.

AEs are measured regardless of relation to Tasigna

Source:

Nilotinib Summary of Clinical Safety: 120-Day Safety Update. Novartis Pharmaceuticals: East Hanover, NJ; 2007.