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About Tasigna®
How to Dose
Tasigna should be dosed 400 mg twice daily (taken as two 200-mg capsules, approximately every 12 hours). The capsules should be swallowed whole with water but no food.
No food should be consumed for at least 2 hours before the dose is taken and no additional food should be consumed for at least one hour after the dose is taken.
- In patients experiencing neutropenia or thrombocytopenia, therapy may be temporarily withheld for up to 2 weeks
- If the AE resolves within 2 weeks, resume therapy at the previously prescribed dose
- If the AE persists, reducing the dose to 400 mg once daily is recommended
- If clinically significant moderate or severe non-hematological AEs develops dosing should be interrupted and may be resumed at 400 mg once daily once the AE has resolved. Re-escalation to 400 mg twice daily should be considered if clinically appropriate.
- In the event of a Grade 3-4 serum lipase, bilirubin or hepatic transaminase elevation, doses should be reduced to 400 mg once daily or interrupted. Serum lipase, bilirubin or hepatics transaminase levels should be tested monthly as clinically indicated.
